2017 projects

Impact of the circadian clock on α- and β-pancreatic islet cell gene transcription and function upon β-cell failure and regeneration

Circadian oscillation of biological processes has been described in light-sensitive organisms from bacteria to human beings, reflecting the existence of underlying intrinsic clocks. Our recent work suggests that α- and β-cellular clocks are oscillating with distinct phases in vivo and in vitro. These cellular oscillators impact critically on the temporal profiles of insulin and glucagon secretion, and on the transcriptional patterns of key functional genes in the islet cells. Parallel analysis of the molecular properties of α- and β-cell oscillators was conducted by establishing a mouse model expressing three reporters: one diagnostic for α-cells,

Read more ...

Globalisation, Migration, and Policy: Europe and Israel

This collaboration aims at setting up a joint research course for advanced MA and doctoral students of our two universities. The course addresses the process of globalisation through the prism of international immigration.

In a nation-based state characterised both politically and ideologically by immigration such as Israel, understanding migration and associated social, cultural, and economic struggles is of particular importance. By contrast, Western European countries have needed to adapt to a multiple waves of migration due to ageing populations,

Read more ...

Living and Fossil stromatolites in the Dead Sea Basin

Stromatolites represent the oldest forms of life and are commonly defined as laminated organo-sedimentary structures built by the trapping, binding and/or precipitation of minerals via microbial processes. Dead-Sea stromatolites have attracted considerable attention and recently have been used to constrain the late Quaternary lake level curve. This closed-basin contains living and fossil stromatolites at a wide range of water salinity, temperature, oxidation state, and  lighting. The basin thus offers a unique opportunity to understand the environmental factors controlling their formation as well as to develop a better chronology for the last glaciation,

Read more ...